Our publications

Baranykova S., Gupta R. K., Kajdasz A., Wasilewska I., Macias M., Szybinska A., Węgierski T., Nahia K. A., Mondal S. S., Winata C. L., Kuźnicki J., Majewski Ł. (2024). Loss of Stim2 in zebrafish induces glaucoma-like phenotype. Scientific Reports, 14: 74909. DOI: 10.1038/s41598-024-74909-0

Link to the article:
https://www.nature.com/articles/s41598-024-74909-0

Salachna P., Wesołowska A., Zawadzińska A., Kańczurzewska M., Sawikowska A., Darras A., Neugebauerová J., Meller E., Pietrak A., Piechocki R., Łopusiewicz Ł. (2024). Flaxseed oil cake improves basil (Ocimum basilicum L.) yield under drought stress by increasing herb biomass and quality of essential oil. Industrial Crops & Products 220: 119295. DOI: 10.1016/j.indcrop.2024.119295

Link to the article:
https://doi.org/10.1016/j.indcrop.2024.119295

Sawikowska A. (2020). Meta-analysis of flavonoids with antiviral potential against coronavirus. Biometrical Letters 57: 13-22. DOI: 10.2478/bile-2020-0002

Link to the article:
https://sciendo.com/article/10.2478/bile-2020-0002

Description of the publications:

Loss of Stim2 in zebrafish induces a glaucoma-like phenotype.

This study investigates the role of Stim2 in the visual system of zebrafish, focusing on its impact on calcium signaling in the retina and its potential link to glaucoma. The research employs various bioinformatics methods, including bulk RNA sequencing and single-cell RNA sequencing, to examine changes in gene expression and cellular composition in stim2 knockout zebrafish. Key findings include a reduction in retinal ganglion cells, thinning of retinal layers, and alterations in GABAergic neurons, all hallmark features of glaucoma. The study underscores the importance of stim2 in maintaining calcium homeostasis and its potential role in retinal neurodegeneration. The bioinformatics analyses included: preliminary processing of data derived from single-cell RNA sequencing; identification of cell clusters and their annotation based on marker gene expression; differential gene expression analysis within clusters and functional analysis (gene ontology); calculation of the ratio of cell counts in the stim2-KO model compared to the wild type.

Flaxseed oil cake improves basil (Ocimum basilicum L.) yield under drought stress by increasing herb biomass and quality of essential oil.

Our research delves into the effects of drought stress on basil, uncovering crucial insights into the plant’s adaptive mechanisms and highlighting the beneficial role of flaxseed oil cake (FOC) in alleviating these stress-induced impacts. Our contribution to the publication is statistics including correlation network analysis. Key highlights include reduced herbage yield and modified essential oil components due to drought stress, with FOC application altering plant specialized metabolites content. Notably, under drought conditions, FOC improved plant biomass and accumulation of linalool and methyl eugenol. The study emphasizes the enhanced nitrogen levels in plant tissues and substrates and identifies fresh weight, dry weight, and methyl eugenol as ‘hub’ traits correlated with most traits. Two-way ANOVA, principal components analysis (PCA), and correlation networks were applied to associate the data.

Meta-analysis of flavonoids with antiviral potential against coronavirus.

We present the results of our work on the SARS-CoV-2 coronavirus. This is a meta-analysis of flavonoids with antiviral potential against coronavirus. We analyzed data containing information about crucial metabolites that neutralize coronavirus: rhoifolin, pectolinarin, and herbacetin. In this publication, we focus on identifying the best sources for obtaining these metabolites. Our research may contribute to the effective isolation of these compounds for drug development.